Four Toronto-area police officers are facing charges following an investigation that began after charges were stayed against an accused drug dealer, who alleged police stole items during a search of his storage locker.Lowell Somerville alleges the Peel regional police officers stole items that included a statue of fictional character Tony Montana from the movie “Scarface,” cash and various items of jewelry.A judge stayed Somerville’s charges of heroin trafficking, and possession of heroin, MDMA and cocaine in May 2017 after concluding the officers knew one of them had taken the statue and “chose not to tell the truth.”Peel police said Thursday that four officers — a sergeant and three constables — have each been charged with single counts of theft under $5,000 and obstructing police, and two counts of perjuryAll of the officers are suspended and are to appear in Brampton, Ont., court on June 4.Chief Jennifer Evans says she immediately ordered an investigation into the conduct of the officers following the court ruling.“Our officers are held to a high standard in order to maintain the trust that we have worked so hard to build with our community,” Evans said Thursday in a statement.Court documents show Peel police were conducting ongoing surveillance of Somerville and, on June 23, 2014, followed him to Toronto, where they saw him make what they believed was a hand-to-hand drug transaction.The person to whom the drugs were believed to have been sold was arrested and found to have about a gram of cocaine in his possession.After discovering the cocaine, police stopped Somerville in his car a few kilometres away and arrested him for trafficking, seizing one gram of heroin and one gram of methamphetamine, the documents say.While searching Somerville’s apartment in Mississauga, Ont., police seized more drugs and also located documents indicating that Somerville leased a storage unit in Toronto, for which they got a search warrant.Someville testified that after being released from custody on June 25, 2014, he went to the storage locker and noticed that things had been re-arranged and that there were items missing.In addition to the Tony Montana statue, Somerville said other missing things included a gold chain with a king of spades pendant, a shoebox containing $25,000 in poker winnings, diamond earrings and gold rings.Video surveillance from the storage facility showed one of the officers taking out a large object, court heard.The officer testified he had taken a heater from a hallway in the facility that had a sign saying “please take” or “free” and all denied removing anything of value from Somerville’s locker.“In my view, there can be no question that the conduct of the police in this case prejudiced the integrity of the justice system,” the judge said in issuing the stay.
Actress Bailee Madison has voiced a fun video to help LA-based Starlight Children’s Foundation launch a brand new campaign called Play in May.Bailee Madison Supports Play In May CampaignCredit/Copyright: Jason Merritt, Getty ImagesThe program highlights the healing power of play for hospitalized teens while raising funds to support Starlight programs.Video: Play in MayStarting May 1, Starlight is asking everyone to pledge to play 15 minutes a day for 15 days. People can choose their favorite way to participate – from apps and video games to even old fashioned games – players just ask friends, family and classmates to support them by making a donation or joining their team. You can learn more by visiting supportstarlight.org or following @StarlightOnline.
Annette FrancisAPTN NewsFinal oral submissions for the National Inquiry into Missing and Murdered Indigenous Women and Girls wrapped up this week in Ottawa.Johannes Lampe, president of the Nunatsiavut Government in Labrador, told the inquiry that reducing the incidents of violence and deaths among Inuit in Labrador is critical.“We are of the view that measurable actions mush be taken in everything,” he said.“The poor social determinants of health, Inuit self-governance, and particularly participation in national, provincial, and territorial governance is the most effective means of ensuring policies, programs, services and practice approach are appropriate of indigenous communities and people.”Katherine Hensel of the Association of Native Child and Family Service Agencies of Ontario urged the commissioners to ensure any proposed federal legislation on child welfare not be limited to children living on reserve.“We know that many…Indigenous children who’ve been in contact with child welfare…are in urban centres or off-reserve, so we will also be urging the commission to make recommendations that the provinces correct and reverse and eliminate the perverse funding incentives that not only don’t fund prevention, but incentivize the removal of children,” she said.During the final two weeks of oral submissions — in Calgary and Ottawa — the commission heard from 53 of the parties with standing.The commissioners are now tasked with analyzing what they’ve heard throughout the inquiry and submitting a final report to the federal government by April 30, email@example.com@APTNAFrancis
Work is expected to begin this coming week, with completion expected sometime in 2020. Mayor Rob Fraser says the new subdivision will serve Taylor’s growing housing needs and fits with the vision Jarvis had for the community.“We’ve hit a limit in Taylor with respect to residential homes, properties that are already serviced. We’ve hit a bit of a wall and for us to move to the next phase in Taylor’s development, as far as bringing in more people, we need another subdivision. The vision of this subdivision goes hand-in-hand with the vision that Fred had for our community. I’m excited to get this going and Fred’s legacy will last forever, really, in this community.”It was announced in February that the subdivision ‘Parcel Z’ would be named in honour of Jarvis.Located along Spruce Street, this parcel is a 22-acre piece of District property that includes 50 lots for new single-family homes.The area for the Jarvis Crescent Subdivision is outlined in red. Source Google MapsIn April, the District awarded a $3.39 million contract to S. Young Enterprises to construct the subdivision, with Urban Systems being awarded a $128,000 direct award for project management services. TAYLOR, B.C. – The District of Taylor held a groundbreaking ceremony on Friday for the Jarvis Crescent Subdivision.The new subdivision is in honour of Fred Jarvis, the late former Mayor of Taylor who passed away on December 2, 2018.Jarvis served 28 years as the Mayor of Taylor and 35 years of public service before he retired in 2014.
“The Secretary-General shares the objective that the report reflect the highest standards of accuracy possible,” said a statement issued by his spokesperson.According to the statement, Mr. Ban has stated repeatedly his alarm at the civilian casualties caused by all parties to the fighting in Yemen and has reminded them of the need to avoid such casualties and move immediately toward a lasting ceasefire.“In this regard, the Secretary-General invites the Coalition to send a team to New York as soon as possible for detailed discussions, ahead of the Security Council’s discussion of the report currently scheduled for August,” said the statement, adding that pending the conclusions of the joint review, Mr. Ban will remove the listing of the Coalition in the report’s annex.In his annual report on children and armed conflict covering the year 2015, the UN chief expressed his shock at the scale of grave violations against children in countries, including Afghanistan, Iraq, Somalia, South Sudan, Syria and Yemen.Mr. Ban noted the complex environments created by aerial operations by some Member States’ armed forces and international coalitions, which killed and maimed many children. In some cases, State-allied armed groups have recruited and used children and committed other violations.“Member States should consider, as a matter of priority, changes in policies, military procedures and legislation, where necessary, to prevent violations and protect children,” he said in the report, stressing that those who engage in military action resulting in numerous violations of children’s rights will find themselves under scrutiny by UN.
Then-sophomore Myles Martin checks the clock as he looks for back-points against Bo Nickal of Penn State on Feb. 3, 2017 at the Schottenstein Center. OSU lost, 32-12. Credit: Nicholas McWilliams | Former Sports EditorOhio State wrestling unveiled its 2017-18 schedule Thursday, which includes 14 dual meets and two tournaments.The reigning Big Ten champion Buckeyes will host six duals during the upcoming season. The competitions will be held in three different cities and four different venues. While St. John Arena is the conventional home for Ohio State wrestling, duals will be hosted at the Schottenstein Center, and at two in-state high schools. The season will kick off on Nov. 4 when the Buckeyes compete in the Princeton Open, a tournament hosted by Princeton in Princeton, New Jersey. Ohio State will then host three non-conference foes at St. John Arena, beginning with Arizona State on Nov. 12. Cleveland State and Kent State will visit Columbus to take part in the Thanksgiving Throwdown on Nov. 21. On Dec. 2-3, the Buckeyes travel west to compete in the Cliff Keen Las Vegas Invitational.The Big Ten opener against Indiana on Dec. 10 will be hosted by the Buckeyes at Cuyahoga Valley Christian Academy in Cuyahoga Falls, Ohio, the alma mater of Nathan Tomasello, the reigning Big Ten champion at 133 pounds. Ohio State will have three straight duals on the road before rounding out regular-season conference play with six weekend matches, including a match against Purdue on Jan. 28 at Graham High School in St. Paris, Ohio, which produced brothers Bo and Micah Jordan. Before beginning postseason play in the Big Ten tournament, Ohio State will travel to Raleigh, N.C. for a dual with North Carolina State on either Feb. 16 or 18, with the official date to be announced at a later time. The Buckeyes will have an opportunity to repeat as conference champions when the Big Ten tournament takes place on March 3-4 in East Lansing, Michigan.If all goes well for certain Ohio State wrestlers, their season will conclude in their home state as the NCAA championships will be held Mar. 15-17 at the Quicken Loans Arena in Cleveland.The season schedule will see Ohio State face seven schools that finished in the top-20 at the 2017 NCAA championships. Ohio State will return a wealth of talent from its 2016-17 roster, including two-time defending national champion heavyweight Kyle Snyder. Returning along with Snyder will be the Jordan brothers, Tomasello, Kollin Moore and Myles Martin.Bo, the elder brother, is the defending Big Ten champion at 174 pounds. Micah, a redshirt junior, finished as a runner-up at 149 pounds in the Big Ten last season. Moore was the reigning champion at 197 pounds, while Martin won the NCAA championship as a freshman in 2016 at 174 pounds. Tue., Nov. 21vs. Cleveland State (Thanksgiving Throwdown)vs. Kent State (Thanksgiving ThrowdownColumbus Fri., Jan. 26vs. Michigan StateEast Lansing, Michigan Jan. 19 or 21vs. IowaColumbus Feb. 2 or 4vs. Penn StateUniversity Park, Pennsylvania Dec. 2-3Cliff Keen Las Vegas Invitational Las Vegas Fri., Jan. 5vs. Maryland College Park, Maryland Sun., Dec. 10vs. IndianaCuyahoga Falls, Ohio Sun., Jan. 28vs. PurdueSt. Paris, Ohio Sun., Jan. 7vs. RutgersPiscataway, New Jersey Feb. 16 or 18vs. North Carolina State Raleigh, North Carolina Sun., Nov. 12vs. Arizona StateColumbus Sun., Dec. 17vs. ChattanoogaAtlanta Fri., Jan. 12vs. Minnesota Columbus (Schottenstein Center) Schedule: Mar. 15-17NCAA ChampionshipsCleveland, Ohio Sat., Nov, 4Princeton OpenPrinceton, New Jersey Sun., Feb. 11vs. MichiganAnn Arbor, Michigan Mar. 3-4Big Ten Championships East Lansing, Michigan
On Monday, multiple prisoners were involved in a lengthy disturbance across two wings at the jail.The incident came on the same day as a report warned the prison had lost experienced staff and last summer suffered problems including violence.Prison affairs academic and blogger Alex Cavendish tweeted: “HMP The Mount: hearing about more trouble this morning. Staff said to have ‘lost control’ of part of Nash Wing. Awaiting more info.” Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings. Riot officers were sent to quell unrest at a Hertfordshire prison for the second time in 24 hours after inmates again took over a wing.The ‘Tornado Team’ of specialist officers was dispatched after staff reportedly lost control of part of Nash wing.The Ministry of Justice confirmed the incident, but said the prison remained secure and there was no risk to the public. He then added: “HMP The Mount: report that Tornado Team has been called in. Command suite set up.”A Ministry of Justice spokesperson said: “Specially trained prison staff have successfully resolved an incident at HMP The Mount on 1 August. There were no injuries to staff or prisoners.“We do not tolerate violence in our prisons, and are clear that those responsible will be referred to the police and could spend longer behind bars.”Meanwhile, prison officers have quelled a disturbance at Erlestoke jail in Wiltshire.A Prison Service spokesman added: “Staff successfully resolved an incident involving a small number of prisoners at HMP Erlestoke on 1 August.”The offenders responsible will be referred to the police and could spend longer behind bars.” HMP The Mount Prison, Bovingdon. Google aerial. The unrest happened less than 24 hours after staff had regained control of two wings on Monday.Officers regained control of the prison for the second time at around 5pm on Tuesday.Staffing shortages and an extended lock down of prisoners are reported to have left the prison as “a disaster waiting to happen”.It is understood prisoners armed with weapons seized control of part of Nash wing, which houses 250 inmates including many who are serving short sentences or have only three months left to serve.
Ausdrill has announced the award of mining contract extensions in both Australia and Africa. Ausdrill’s Australian drill and blast division has successfully negotiated a contract extension with thermal coal producer Ensham Resources for a further term of three years, worth approximately A$36 million. The contract is for the provision of drill services at the Ensham coal mine in the Bowen Basin, Queensland. Ausdrill will utilise four blast hole drills and one exploration drill, along with 35 personnel at this site, to drill in the order of 110,000 m per month. Subsidiary African Mining Services has, for the sixth consecutive year, successfully renegotiated the exploration drilling contract at the Ahafo gold mine in Ghana, owned and operated by Newmont. The contract will generate revenue of approximately $8 million over a period of 12 months.The Ahafo deal extends African Mining Services’ relationship with Newmont at the mine where AUMS – African Underground Mining Services (a 50/50 joint venture between Ausdrill and Barminco) is also carrying out work at the Subika underground project. Ausdrill’s Managing Director, Ron Sayers, said: “It is pleasing to see the renewals of contracts where Ausdrill has had long term relationships with our clients. From day one we have built this business on the basis of developing strong, lasting relationships with our clients. We have a number of major contracts that are due for renewal in the next six months and we anticipate we will secure these.”
Denison Mines and Fission Uranium have executed a Binding Letter Agreement to combine their respective businesses. The Transaction creates a leading Canadian focused diversified uranium company – combining high quality assets and the management teams of two highly respected companies. Headlining the asset portfolio of the combined company will be two world class uranium exploration and development projects: Fission’s 100% owned Patterson Lake South Project, and Denison’s 60% owned Wheeler River Project, both located in the prolific Athabasca Basin, in Northern Saskatchewan, Canada.The combined company, to be named ‘Denison Energy Corp’, will be approximately 50% owned by each of Denison’s and Fission’s existing shareholders on a fully-diluted in-the-money basis. The market capitalization of Denison and Fission on a combined basis is anticipated to be some C$900 million.Ron Hochstein, Executive Chairman of Denison, commented: “The continued exploration success at our Phoenix deposit and Gryphon discovery, in combination with the discovery and exploration success of the world class Triple R deposit puts the combined company in an incredibly strong strategic position, with the most significant development portfolio in the world. We are confident that our shareholders will benefit from the value creation opportunities that will be realised through an expanded and more diversified uranium company.”Dev Randhawa, Chairman & CEO of Fission, stated: “This merger will create the uranium industry’s leading exploration and development company at a time when the sector is poised for growth. Denison has a strong, diversified portfolio and, with the Triple R deposit, Fission is bringing the Athabasca Basin’s largest undeveloped high-grade resource as well as a successful and award-winning technical and management team.”Transaction HighlightsConsolidation of strategic uranium assets: An unrivalled portfolio of strategic uranium asset interests in the Athabasca Basin, headlined by Fission’s 100% owned PLS Project and Denison’s 60% owned Wheeler River Project and including Denison’s interests in the Midwest, McClean Lake, Waterbury Lake, Mann Lake, and Wolly projects, as well as Denison’s strategic 22.5% ownership interest in the McClean Lake MillContinued exploration potential: Exploration foothold in both the historically prolific Eastern Athabasca Basin and the emergent Western Athabasca Basin, with a dominant combined land package of over 430,000 ha and a sizeable base of mineral resources defined under NI 43-101, providing the foundation for future resource growthFree cashflows: The toll-milling of ore from the Cigar Lake mine under a toll milling agreement between the McClean Lake Joint Venture and the Cigar Lake Joint Venture and management fees from Uranium Participation Corp are expected to provide the combined company with a source of cash in the future to fund its activitiesComplimentary combined management team: Management from Fission and Denison will be combined, offering expertise and skill in the uranium industry and mergers and acquisitions, as well as the proven ability to finance ambitious exploration programs and successfully explore and develop uranium mining projectsIncreased liquidity: Increased scale is expected to enhance trading liquidity and access to global capital marketsValuation upside: Various monetisation options in respect of Denison’s African exploration and development portfolio, including the Falea project in Mali and the Mutanga project in Zambia, are being considered by the combined company and may be pursued when market conditions permit.The senior executive team and the Board of Directors of the combined company will draw from the extensive experience and expertise of both companies. Lukas Lundin will become non-executive Chairman and Dev Randhawa will become the Chief Executive Officer of the combined company. Ross McElroy will be appointed President & Chief Operating Officer, and David Cates will become Chief Financial Officer. The Board of Directors will be comprised of ten directors: five of whom currently serve as directors of Denison and five of which will be appointed from the Board of Directors of Fission.
Alexandrina Cabral BarbosaBojana PopovićCecilie LegangerChehovski MedvediEdin BasicFrantisek Sulchandball investmentsJohan SjostrandTOP 10 handball ← Previous Story THW Kiel lost the Championship Race in Germany? Next Story → Goppingen coach criticizes German players The ending stage of the season is the right time to make conclusions about what we saw from September 2010. That is why Handball-Planet.com made a list of the best investments of the players, which made a huge progress for their new teams in 2010/2011 or individual skills.TOP 10 Handball Investment in 2010/2011:1. Alexandrina Cabral Barbosa (25 – Itxako)The biggest surprise of the Women’s EHF Champions League, Spanish Itxako brought to European handball a group of fantastic players. One of them is the Portuguese left-back, Alexandrina Cabral Barbosa, 7th goalscorer of the EHF CL with 6,3 goals per match in the Main Round thanks to which the Spanish champion qualified for the semifinal. Before she came to Itxako, Barbosa played three years in Romanian’s Rumentul.2. Bojana Popovic (32 – Budućnost Podgorica)After five EHF CL trophies, she came back to Montenegro to win EHF Champions League with the team, where she made a huge individual progress at the beginning of last decade. They are in TOP 4 and going further. Popović motivated handball fans, political authorities and other structures of society. That is something what is a precondition for success.3. Johan Sjostrand (24 – F.C Barcelona)In their search for a new “Svensson”, F.C Barcelona decided to sign contract with young Swedish star and didn’t make a mistake. Playing for the Swedish national team or for F.C Barcelona, Sjostrand shows huge motivation and mental strength. He is a bright future of one of the biggest handball team ever…4. Katrin Lunde Haraldsen (31 – Gyori)This was one of the biggest transfers at the beginning of the season. That was approved almost after the first match of Katrin Lunde in a new team. She left Scandinavia, but her skills went with her. The main trump in Gyori’s dreams about EHF CL title…5. Cecilie Leganger (36 – Larvik)She is not too young, but her name is Cecilie Leganger. Larvik is on the way to make something big with her between the posts…6. Edin Basic (32 – Chambery Savoie)The best season in his professional career playing in France. He moved from Swiss Amicitia last summer, but nobody expected that Chambery will be a TOP 16 team in Europe with Bašić in the TOP 10 scorers of EHF CL, leader in France, etc…7. Frantisek Sulc (32 – Pick Szeged)After almost 15 years of professional career, Slovak playmaker, Frantisek Sulc got the chance to play in EHF Champions League and become the “first scorer” of Hungarian vice-champion, Pick Szeged. As 9th scorer of the EHF CL, Sulc showed that he was a “great hit” of the team from the city, where handball is very popular…8. Sven-Sören Christophersen (26 – Fuchse Berlin)Fuchse Berlin Management bought 26 years old left back from HSG Wetzlar and in small period of time, Sven Soren Christophersen became a vital part of the strong team, the best scorer, etc. Fuchse are on the way to the first European season and people from the club can be satisfied with the job they did so far…9. Mikkel Hansen (24 – AG Copenhagen)Maybe it isn’t the right time to make conclusions in this case, but Mikkel Hansen showed to the handball world that he became the best shooter on the Planet at WC 2011 in Sweden. It is obvious that Kasi Jensen wants to make from him a Danish sports legend for many years ahead. AG will play in EHF CL from the next season and then we will say something more…10. Alexander Petersen (31 – Fuchse Berlin)He didn’t get his chance in SG Flensburg along Oscar Carlen and he left the North. In the capital city, the Icelandic right wing-back showed his TOP class. Fantastic player…
LIFESTYLE “VICES” ARE cutting life expectancy and pushing up life insurance premiums, according to insurance company Caledonian Life.The company has cited expert research by the Irish Heart Foundation showing that 39 per cent of Irish adults are overweight and 25 per cent are obese – which is in turn causing premiums to rise.The company also states that 7,000 people die from smoking related disease in Ireland every year, which is just one of the lifestyle characteristics which are pushing up the life assurance premiums of certain demographics in the country.Lifestyle ‘vices’ such as smoking and alcohol consumption are all taken into account when pricing a policy, the company says.“When we underwrite Specified Serious Illness and Life assurance applications, the most common medical issues that we encounter are obesity, elevated lipids (cholesterol) and hypertension (raised blood pressure). There has also been a rise in the numbers of applicants with Type 2 Diabetes which is often related to obesity,” said Daragh Feely Sales Manager at Caledonian Life. “A higher than average Body Mass Index (BMI) continues to be a tell-tale sign of potential problems down the road for many people.”If a person is obese and has additional medical conditions such as diabetes or high blood pressure they could have difficulty getting approved for life assurance and, where it is approved, they will invariably pay considerably more, Feely said: “A doubling or more of an applicant’s premium due to obesity used to be unusual, but not any more.”Paddy Mahony a Chartered Accountant and Director at online Insurance intermediary SmartQuotes.ie added: ”Underwriters are particularly conscious of obesity, smoking and alcohol intake as they do not exist in a vacuum; they can lead to other serious health conditions, which is why it can affect your Life assurance rates.”Those who are considered underweight may also be asked to undergo a medical examination.However, Caledonian also notes numerous exceptions and variations among life assurance companies – and that senior citizens (aged over 65) are often held to less strict weight standards.Read: New rules on advertising of ‘unhealthy’ food and drink to children>Read: Does a junk food diet lower children’s IQ?>
Tweet thisShare on FacebookEmail this article 51 Comments JUST AFTER 6PM today, John Delaney brushed by the journalists waiting to ask him questions as he left Committee Room 4 at government buildings, explaining that he had a “long day.”Long… but hardly taxing.Delaney was described by the FAI’s Honorary Life President Denis O’Brien in the John the Baptist documentary as being “made of different characters really; he is a collage of people”, but today this sporting administrator of infinite versatility allowed the other characters in the room to do the talking.The FAI delegation arrived at around 9.45am; Delaney among them wearing a Uefa-branded jacket. The committee meeting began at 10am and was twice adjourned within its first hour.First, President Donal Conway unexpectedly produced a Grant Thornton ‘verified’ report about the €100,000 loan, to which the committee took 10 minutes to read.Then it was announced that John Delaney would make an opening statement, which also hadn’t been anticipated.Although Donal Conway’s address had been submitted to the Committee on Monday, Delaney’s oddly wasn’t. So the committee took another 15 minutes to read Delaney’s statement…and then took another 15 minutes in private session to consider its implications. Source: TheJournal.ie/YouTubeThe kicker line: “On legal advice, I am prevented from making any further comment in relation to the finances of the Association or my former role as CEO or the €100,000 payment either directly or indirectly.”At the resumption, Delaney read the statement. Then, at 11.52am, he faced his first question, from Catherine Murphy.There was a brief pause as Delaney wrote on the notepad in front of him, then he laid down his pen, lifted his head and replied, “Deputy, I’ve made it clear from my statement that on legal advice, I can’t add anything to what I’ve said.”President Donal Conway then took on the job of answering the questions that came the delegation’s way.When Robert Troy pressed Delaney for an answer in response to a question about Bray Wanderers, Conway said he’d respond; a back-and-forth ended with Chair Fergus O’Dowd flicking over Delaney’s statement and deciding that Conway should take the question.Delaney remained mute until 12.24pm, when he asked to leave the room for a “comfort break.”This was presumably meant as a break from the comfort.Later, Ruth Coppinger asked Delaney whether he felt it is fair he is answerable to the general public, to which he replied, “I’ve read my statement as it is”, and left it at that.At the lunch-time interval, Delaney’s score of Questions Answered to Comfort Breaks Taken read 3-2: he took another as Senator Mark Daly argued that he deserved more time after a rambling, confusing oration on the need for gender equality.It veered via Brexit – “all the women” would have solved it by this stage, apparently – and didn’t end in a question, so he spent much of his allotted time foostering about, forlornly foraging for a full stop or a question mark in conduct unbecoming of a man who finished third in a reality TV show called Treasure Island.Amid it all, President Donal Conway did the talking.We learned at least that three members of the board – then-CEO John Delaney, then-president Tony Fitzgerald and then-Honorary Secretary Michael Cody – knew about the April 2017 cash flow issue and Delaney’s decision to loan the Association €100,000.The rest of the Board learned of the issue on 4 March this year, which contradicts the FAI’s 18 March statement saying that the “the Board of the FAI has been kept fully informed in relation to this matter at all times.”The FAI, however, couldn’t confirm who signed off on this public statement, with Director of Communications Cathal Dervan saying that he will furnish the Committee with that information when he returns to work at Abbottstown.When questioning Conway about the loan, Catherine Murphy contended that the issue was “managed out of sight of the board”, to which the President replied with an FAI quote for the ages.It was managed the way it was managed.Put that over the door at Abbottstown.We broke for lunch with Chair Fergus O’Dowd asking the FAI to consider “regime change” during lunch, albeit probably not expecting them to enact it over the course of 75 minutes.After lunch, a lot of the attention switched away from Delaney and Conway, although Michael Healey Rae didn’t get that memo as he launched a lengthy hagiography of Delaney, declaring that if the former CEO was guilty of anything, it was of working hard for the Association; promising Delaney “what I call ‘the mother of all welcomes when you come to Kerry.”Coppinger retorted by calling Healy-Rae a “joke”, given he hadn’t actually asked a question. Healy-Rae isn’t a member of the committee, but was entitled to turn up and he had sat patiently in the room since 10am to deliver his support to Delaney.Having not spoken during the first half of the day, Honorary Treasurer Eddie Murray was then brought into the fray by Noel Rock and Jonathan O’Brien, and Murray’s squirming under questioning brought a series of startling revelations.As the FAI’s Honorary Treasurer, he said he didn’t feel undermined having not been informed about the loan, and he could not independently say whether the FAI have always had an active tax clearance certificate. Source: TheJournal.ie/YouTubeThe Honorary Treasurer also said that he believed the FAI had one bank account; the Association’s delegation clarified just less than an hour later that they have 24 of them. Just the 23 off, then.Elsewhere, when pressed repeatedly on whether the FAI Board would step down if Sport Ireland make it a condition of the reinstating of their funding, Conway eventually said that “we will not jeopardise sports council funding, so we’ll take whatever action we have to take.”There was one final break, during which a group of schoolchildren arrived into the Committee room on a tour. The FAI delegation returned before they left, allowing Delaney to shake the hand of every student in a brief return to the kind of work he may find himself denied in his new role.Frustration fomented among the committee members across the day: Robert Troy decried the FAI for being “evasive and non-committal”, saying that the outside perception is that the Board is a “cartel”; Imelda Munster reckoned there were people looking on saying ‘scarlet for ya’ and said she believed Delaney had behaved “disgracefully”; Ruth Coppinger said that while Delaney was present physically, his refusal to answer the questions the public expected of him meant the whole show was akin to “Hamlet without the Prince.”With its full cast, Hamlet is considered a tragedy.What do we call this? Apr 10th 2019, 9:06 PM Image: Laszlo Geczo/INPHO 25,715 Views Comfort breaks, a Healy-Rae and Brexit? John Delaney’s ‘long’ day at Leinster House Ruth Coppinger said that Delaney’s refusal to fully engage with all questions, citing legal advice, turned today’s hearing into “Hamlet without the prince.” Short URL John Delaney arrives at Leinster House with President Donal Conway. Image: Laszlo Geczo/INPHO Wednesday 10 Apr 2019, 9:06 PM https://the42.ie/4586402 John Delaney arrives at Leinster House with President Donal Conway. By Gavin Cooney Share23 Tweet Email
Facebook Twitter: @NeosKosmos Instagram A simple idea of giving back to the community was what drove three Adelaide men in creating The GoTo Foundation – a foundation making a big difference. Established in April 2010, by George Diakomichalis, Nick Apostolou, Lewis Pounentis, the GoTo Foundation is a non-profit organisation geared towards the improvement of health, wellbeing and education of individuals and groups by assisting to provide essential services for the benefit of all South Australians. Through events, fundraisers and gigs, the foundation is about to embark on its biggest challenge to date – riding from Melbourne to Adelaide for the Flinders University Autism Early Intervention Program (EIRP). George Diakomichalis, told Neos Kosmos that they need to think big to raise the big money for the program. “We do a lot of events. Every year we have Mirror Balls and Happy Pants, an 80s dance night, we have quiz nights, but we knew for this program we had to do something big.” The charity bike ride will start at Federation Square, Melbourne on Sunday 16 October and finish in Gawler Place, Rundle Mall, Adelaide on Saturday 22 October. The nine riders will cover a total of 895 kilometres and will ride through Melbourne, Ballarat, Hamilton, Penola, Kingston SE, Meningie, Murray Bridge and then Adelaide. With a target to raise $100,000, the boys are already halfway there. “We needed to do something big for people to donate; we needed to aim big. This way we can get corporate sponsorship and are able to have different levels of sponsorship,” said Diakomichalis. All three philanthropists have full-time jobs, are business owners, family men, so to find the time to add this to their task list seems exhausting. “It’s very demanding but it’s also very, very rewarding,” explained Diakomichalis. “When we started the foundation, the public responded really well, so we’ve gone the whole hog. Between the three of us, it’s a full-time job with what we do, with organising, meetings, but it’s something that we love. “The fact we are giving back to the community and the appreciation and the satisfaction you get from helping is something magnificent. “And it’s a great lesson for me personally, for my two young daughters. They’ve learnt a lot about charity and how helping people is rewarding. I think it’s a positive thing for everyone.”
Facebook Twitter Google+LinkedInPinterestWhatsAppBahamas, April 7, 2017 – Nassau – Today the Commissioner of Police, in his capacity as Provost Marshall read, from the steps of Parliament, two Proclamations from Her Excellency the Governor General. The first Proclamation Prorogued Parliament on the 7th April, 2017 and the second Proclamation gave Notice of the return to Parliament on 11th April, 2017.The Minister of National Security, responsible for Parliamentary Elections, urged Bahamians to get registered to vote, so that they can exercise an important franchise afforded to lawfully qualified citizens. The last day to register to vote will be the 10th of April.Registration Centres will be open from 9am to 9pm through Saturday of this week. On Monday, 10th April all registration centres will open at 9am and close at 5pm. After this point, no citizens will be able to register to vote in the upcoming elections.Beginning Tuesday 11th April, 2017, registered voters in New Providence will be able to collect their Voter’s Card at the Parliamentary Registration Department Headquarters, Farrington Road, and in the Family Islands at the office of the Family Island Administrator.#MagneticMediaNews#letsvoteBahamas#getoutandregister#BahamasGeneralElections2017 Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:
Facebook Twitter Google+LinkedInPinterestWhatsApp Facebook Twitter Google+LinkedInPinterestWhatsApp#Turks and Caicos, September 6, 2017 – Providenciales – It is always our privilege as the corporate telecommunications partner of DDME to assist during times of natural disaster and emergencies, as our country is anticipating a Category 5 Hurricane in less than 48hrs. We are happy to announce that we have supplied the DDME with handsets, charging devices, credit and data for the shelters, and first responders valued at over US$4000.00.The presentation was made today by FLOW Country Manager, Mrs Delleriece Hall, and FLOW Marketing Communications Executive, Mr Darron Hilaire to Director of DDME, Dr Virginia Clearveaux and team.“We are super grateful for the donation Flow made to the department today in light of the traveling storm, Hurricane Irma, that is approaching the Turks and Caicos Islands. This will ensure that we can continue to communicate with our shelter managers, first responders and the general public”, remarked Director, DDME, Dr Virginia Clearveux.Flow will continue to provide SMS updates around the clock—before, during and after the storm as we receive information regarding Hurricane Irma from the DDME.Flow customers are asked to inform family members and friends NOT receiving SMS updates to send an email to firstname.lastname@example.org to be added to the subscriber list.Be safe, and prepare!Press Release: FLOW Related Items:
Virat Kohli.GIANLUIGI GUERCIA/AFP/Getty ImagesIndian cricket team skipper Virat Kohli got a major injury scare during his match-winning knock against West Indies in the third and final ODI of the series against West Indies on August 14. The 30-year-old cricketer can be out of the first Test against West Indies due to this minor niggle.During the post-match press conference, the prolific cricketer said that he does not think that it is a fracture, it’s just a split nail. He also mentioned that he was lucky and he will probably feature in the first Test against West Indies.”I don’t think it’s a fracture otherwise I wouldn’t have continued (batting). It’s just a split of the nail,” he said as quoted by PTI.”Luckily, it’s not broken. When I got hit I thought it was worse than what it turned out to be. But it’s not broken so I should be good for the first Test,” he further added.The incident that happened when Kohli was on his way to guide Team India home once again. In the 27th over of the match, Kemar Roach delivered a bouncer which gave a blow to the Indian cricketer’s right thumb and he was immediately attended by the team physio after which the cricketer continued to bat to take India home. Shreyas Iyer and Virat Kohli.TwitterThe 30-year-old batsman also became the leading run-getter in a decade in international cricket as he became the first batsman to score 20,000 runs in 10 years.The Men in Blue defeated West Indies by six wickets in the rain-interrupted fixture at the Queen’s Park Oval, Port of Spain. West Indies batted first and posted a total of 240 runs for the loss of seven wickets. Chris Gayle was the highest scorer for the Carribean with 72 runs from 41 balls. In response, India had to chase the revised target of 255 runs in 35 overs. With Kohli leading from the front and Shreyas Iyer supporting him India reached the target by the 32.3 overs. The Indian skipper scored yet another ton finishing with 114 off 99 balls whereas Iyer scored 65 runs from 41 balls.Team India won the ODI series 2-0. They will next face West Indies for the two-match Test series which starts from August 22.
Helping Earth Loving People (H.E.L.P), a nonprofit organization is hosting the Art for Change (A4C) art showcase entitled: Art for Humanity on Aug. 18 at Busboys & Poets at 5th and K Street NW from 8 p.m. to 11 p.m. The art showcase will feature artwork from local artists and photographers. All the artwork is up for sale and there will also be an art auction featuring donated work. All the proceeds will go to the Art for Change (A4C) youth program. For more information please email us at helpingearthlovingpeople@gmail. com or visit our website at helpingearthloving. wix.com/helpingearth.
© 2016 Phys.org Citation: Plant cellulose prevents short circuits in batteries (2016, July 22) retrieved 18 August 2019 from https://phys.org/news/2016-07-cellulose-short-circuits-batteries.html In a new study published in Nano Letters, researchers from the Ulsan National Institute of Science and Technology (UNIST) in South Korea have designed a cellulose nanomat, or “c-mat,” separator membrane that contains a thin layer of nanoporous plant cellulose on top of a thick macroporous polymer layer. By finely tuning the thicknesses of the two layers, the researchers were able to design a separator membrane that delicately balances the tradeoff between preventing leakage current and supporting fast ion transport. With its tiny pores, the nanoporous cellulose layer prevents leakage current between electrodes, preventing short circuits. On the other hand, the macroporous polymer layer’s porous channels are too large to prevent leakage current between electrodes, but their large size enables them to function like “ionic highways” to rapidly transport charges.The new separator has another major advantage: At high temperatures (60 °C), batteries with the new separator membranes have an 80% capacity retention after 100 cycles, whereas batteries with typical commercial polymer separators maintain just 5% of their initial capacity after 100 cycles at the same temperature.The researchers explain that the large capacity loss in the commercial batteries at high temperature occurs due to unwanted side reactions between lithium salts and water, which produces harmful byproducts such as manganese ions. The nanoporous cellulose-based layer of the new separator membranes has a manganese-chelating ability, so that it binds to the manganese ions and prevents them from participating in the reactions that cause capacity loss. In addition, the macroporous polymer layer captures the acidic reactants that produce the manganese ions, resulting in fewer of these ions in the first place.”We demonstrate in this work that the chemically active cellulose-based c-mat separator can mitigate the manganese ion-induced adverse effects,” coauthor Sang-Young Lee, Professor at UNIST’s School of Energy and Chemical Engineering, told Phys.org. “This enables a remarkable improvement in the high-temperature cycling performance far beyond that which is attainable with conventional membrane technologies.”In the future, the researchers plan to modify the separators for potential use in next-generation rechargeable batteries such as sodium-ion, lithium-sulfur, and metal-ion batteries. “The c-mat separator is expected to be used for next-generation high-performance batteries with high temperature stability—for example, in large-sized batteries for electric vehicles and grid-scale electricity storage systems,” Lee said. In addition to its use as a battery separator membrane, the c-mat separator also has potential applications in membranes for desalination systems, as well as for ecofriendly sensors for heavy metal ions. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: Jung-Hwan Kim et al. “Functionalized Nanocellulose-Integrated Heterolayered Nanomats toward Smart Battery Separators.” Nano Letters. DOI: 10.1021/acs.nanolett.6b02069 Journal information: Nano Letters Ternary-layered separator to retard the shuttle of polysulfides towards highly-stable lithium–sulfur batteries Cellulose that originates from plant material is used as a thin layer in a new separator membrane for batteries, resulting in a large increase in capacity retention at high temperatures. Credit: Kim et al. ©2016 American Chemical Society Explore further (Phys.org)—In order to prevent short circuits in batteries, porous separator membranes are often placed between a battery’s electrodes. There is typically a tradeoff involved, since these separators must simultaneously prevent leakage current between electrodes while allowing ions to pass through the porous channels to generate current. Conventionally, these membranes are made of synthetic materials, such as polymers.
Related Content News | Cardiovascular Ultrasound | April 30, 2019 New Guideline Published for Evaluation of Valvular Regurgitation After Catheter-based Valve Interventions A new document compiled by four cardiac imaging professional societies provides a resource to guide clinicians in best… read more Cardiac ultrasound technology has advanced to keep up with several trends. These include improved workflow for greater efficiency, expanded use of qualification metrics, expanded use of 3-D echo to speed exam times and improve operator reproducibility, and expanded use of 3-D transesophageal echo (TEE) to aid guidance in the growing area of transcatheter structural heart procedures. Here are a few examples of how the newest technology is addressing these trends.Improving ReproducibilityA major issue in ultrasound is the variation between operators, which leads to different measurements for the same anatomy in the same patient based on operator experience and technique. Operator variability may also limit the use of ultrasound as a cardiac triage tool as it expands into point of care.3-D echo may solve part of this issue by enabling acquisition of volume datasets, rather than very specific slices of the anatomy. A 3-D volume acquisition allows a cardiologist reviewing the exam to select the optimal slices during post-processing, instead of relying on the echo tech to get the specific 2-D views. Some high-end ultrasound systems already extract the ideal views automatically.In addition, most high-end echo systems now automatically quantify measures such as ejection fraction, left ventricular mass and strain values. An example of this is GE Healthcare’s Automated Function Imaging (AFI) software on several of its systems, which automates 2-D speckle tracking to measure in real time the deformation (strain) of the myocardial wall. The algorithm tracks the wall motion and calculates the percentage of lengthening or shortening in a set of three longitudinal 2-D image planes (apical long, two chamber and four chamber) and displays the results for each plane. It then combines the results of all three planes in a single bull’s-eye summary, which presents the analysis for each segment along with a global peak strain for the left ventricle.In 2013, Philips Heathcare introduced its new Epiq ultrasound platform. The system was built from the ground up with new technology and software, including use of Philips’ Anatomical Intelligence software, which is designed to help operators get the optimal views needed for specific exams and measurements. Anatomical Intelligence has artificial intelligence components that on later editions will eventually help identify what anatomy and organs are being imaged and from what direction, which can help guide less experienced operators to get perfect exam views. Only about 25 percent of the Anatomical Intelligence software is currently deployed in the first version of Epiq’s cardiology release. Much of it offers ideal illustrations to show the operator how images should appear for specific views. This and other workflow improvements for mitral valve evaluations can cut these exams from 10 minutes down to two to three minutes, Philips said.Epiq’s nSIGHT technology is a new imaging architecture that provides highly detailed images and temporal resolution, allowing for clinicians to see new levels of tissue uniformity and penetrate at higher frequencies for improved views of typically difficult-to-image patients.Workflow and Image Quality ImprovementsAt the 2014 American College of Cardiology (ACC) meeting in March, Esaote premiered its new CrystaLine imaging technology that improves ultrasound’s diagnostic efficiency by enhancing image clarity and providing clinicians the ability to personalize image quality for each patient. The technology contains several workflow enhancements to help clinicians efficiently and effectively manage their increased workload with the expected influx of new patients in the coming years.XView+ and CPI are two CrystaLine features that enhance diagnostic confidence and improve clinical workflow by increasing image clarity across patient populations, from obese to pediatric. XView+ is a unique speckle reduction algorithm that provides multiple levels of noise reduction so sonographers can personalize image quality by “dialing in” the right amount for each patient. CPI improves image quality at depth so sonographers can more effectively image structures deeper within the body of large and difficult-to-scan patients. Images for all patients now yield better anatomical definition throughout extended fields of view, leading to a more confident interpretation of image data.Toshiba America Medical Systems launched its new cardiovascular echo platforms in 2013, the Aplio 500 and Aplio 300 CV (cardiovascular) systems. Both are for premium 2-D cardiac exams and feature Toshiba’s 2-D Wall Motion Tracking technology, which provides visualization and quantitative analysis of myocardial wall motion with accuracy and reproducibility. The systems offer on-board cardiac quantification measurements in all directions (radial, circumferential, 2-D rotation and longitudinal). Additional cardiac-specific technologies include tissue enhancement, advanced dynamic flow, lateral gain controls, tissue Doppler, stress echo, Flex-M mode and auto IMT. Both systems are designed for ease of use with ergonomics in mind and a smaller footprint.True 3-D Echo VisualizationAt the 2013 Transcatheter Cardiovascular Therapuetics (TCT) meeting, GE unveiled its XDclear technology, which increases penetration by 2-4 cm and improves high-definition resolution throughout the image. It also allows true 3-D visualization for echo images created by the Vivid E9 ultrasound system. It uses 3-D echo datasets to create a 3-D image on screen. When the operator wears a pair of PolarVision glasses, the image becomes true 3-D, making it much easier to differentiate depth. To further enhance this feature, GE also created Depth Illumination, which aids depth perception with the addition of synthetic shadowing. It makes anatomy look more like a real surgical view, as if the patient’s anatomy is exposed and seen under surgical lighting. GE demonstrated these combined technologies from a recorded MitraClip procedure on 3-D/4-D TEE. It offered a very clear image of the device’s position, which is often not very clear on traditional 2-D or 3-D TEE.TEE AdvancesWith the growing number of new transcatheter procedures for mitral valve repair, transcatheter aortic valve repair (TAVR), left atrial appendage (LAA) closure and closure of atrial septal defects (ASDs) and ventricular septal defects (VSDs), 3-D TEE is becoming an essential tool for procedural navigation.In 2013, Philips updated its CX50 xMatrix portable ultrasound system to interface with its live 3-D TEE. The smaller footprint is expected to make it more competitive in the cath lab and hybrid OR environments. Its architecture also supports Philips’ EchoNavigator, which aligns TEE views with live fluoroscopy.GE’s Vivid E9 Breakthrough 2012 (BT12) cardiac ultrasound system includes a 3-D/4-D TEE probe, offering tools to improve workflow through simplified image acquisition. It is designed for intuitive navigation and yet easy-to-use quantification. The TEE probe allows 4-D dataset acquisitions. The probe includes triplane imaging, 4-D views and high frame rates. It enables one-button acquisition of mitral valve images, rather than using the track ball and a combination of buttons to slice the image into different views. In bi-plane mode, it has the ability to tilt and rotate at the same time. The system also offers laser lines, a new tool to help understand the relationship between 2-D slices and 4-D views, helping to visualize the linkage between 2-D and 4-D.Siemens fourSight TEE View enables 3-D acquisition, reconstruction and display at the point of care. Both 2-D and 3-D assessment can be combined with the use of a V5Ms transducer. Reconstruction can be done immediately or at a later date. FacebookTwitterLinkedInPrint分享 News | Cardiovascular Ultrasound | August 07, 2019 Contrast Use in First Transthoracic Echocardiogram for Heart Failure Reduces Repeat Testing Heart failure is the fourth most common cause for all admission to U.S. hospitals, and it is the most common reason for… read more Technology | Cardiovascular Ultrasound | July 02, 2019 Philips Extends Advanced Automation on Epiq CVx Cardiovascular Ultrasound Platform Philips recently announced new advanced automation capabilities on its Epiq CVx and Epiq CVxi cardiac ultrasound… read more News | Cardiovascular Ultrasound | June 20, 2019 Bay Labs Announces New Echocardiography Guidance Software Data at ASE 2019 Scientific Sessions Bay Labs announced that new data on the company’s first-of-its-kind deep learning investigational guidance software… read more 360 Photos | Ultrasound Imaging | July 11, 2019 360 Degree View of a Smartphone Performing a Cardiac Ultrasound Exam This 360 degree photo shows a basic, point-of-care cardiac echocardiogram being performed using a smartphone turned i read more 360 Photos | Ultrasound Imaging | July 08, 2019 360 Degree View of an Echocardiography Exam on the SC2000 System This is a 360 degree view of a live cardiac echo demonstration for the Siemens Healthineers Acuson SC2000… read more 3D Auto RV application image courtesy of Philips Healthcare 360 Photos | Ultrasound Imaging | July 09, 2019 360 Degree View of a Mitral Valve Ultrasound Exam on a Vivid E95 System A view of a mitral valve on a GE Healthcare Vivid E95 … read more Feature | July 03, 2014 | Dave Fornell Trends and Advances in Cardiac Ultrasound Recent technical advancements have been designed to improve workflow, qualification News | Ultrasound Imaging | June 27, 2019 FDA Issues Final Guidance on Marketing Clearance of Diagnostic Ultrasound Systems and Transducers The U.S. Food and Drug Administration (FDA) issued the final guidance: Marketing Clearance of Diagnostic Ultrasound… read more News | Cardiovascular Ultrasound | July 02, 2019 Konica Minolta Healthcare Partners With DiA Imaging Analysis for AI-based Cardiac Ultrasound Analysis DiA Imaging Analysis has partnered with Konica Minolta Healthcare Americas Inc. to expand analysis capabilities of… read more News | Cardiovascular Ultrasound | August 05, 2019 Digital Health Devices Used at Point of Care May Improve Diagnostic Certainty A West Virginia-based rural medical outreach event showcased the use of point-of-care technology in an ambulatory… read more
News | February 20, 2015 Scientists Use MRI to Visualize Pancreas Inflammation in Early Type 1 Diabetes Technique could be used to predict likelihood of developing diabetes, improve treatment News | Magnetic Resonance Imaging (MRI) | August 06, 2019 Canon Medical Introduces Encore Orian MR Upgrade Program Canon Medical Systems USA Inc. is helping to provide low-cost patient care solutions for its customers with the launch… read more Related Content Technology | Neuro Imaging | August 07, 2019 Synaptive Medical Launches Modus Plan With Automated Tractography Segmentation Synaptive Medical announced the U.S. launch and availability of Modus Plan featuring BrightMatter AutoSeg. This release… read more Technology | Interventional Radiology | August 16, 2019 Profound Medical Receives U.S. FDA 510(k) Clearance for Tulsa-Pro Profound Medical Corp. announced it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to… read more News | Neuro Imaging | August 16, 2019 ADHD Medication May Affect Brain Development in Children A drug used to treat attention-deficit/hyperactivity disorder (ADHD) appears to affect development of the brain’s… read more News | Focused Ultrasound Therapy | July 10, 2019 Insightec’s Exablate Neuro Approved With GE Signa Premier MRI in U.S. and Europe GE Healthcare and Insightec announced U.S. Food and Drug Administration (FDA) approval and CE mark for Insightec’s… read more Feature | Contrast Media | July 18, 2019 | By Greg Freiherr How To Manage Risk in the MR Suite Macrocyclic contrast agents have the best safety profile of all the magnetic resonance (MR) contrast media that are n read more February 20, 2015 — A pilot study led by researchers at Joslin Diabetes Center has revealed that it is possible to use magnetic resonance imaging (MRI) to “see” the inflammation in the pancreas that leads to type 1 diabetes. This discovery could be a boon for research on methods to slow or halt the disease at an early stage, and could also guide insights into how diabetes progresses.The clinical study, published in the Proceedings of the National Academy of Sciences, tested the possibility of imaging inflammation in the pancreas of human volunteers using ferumoxytol, a coated iron nanoparticle approved by the U.S. Food and Drug Administration (FDA) as an iron replacement therapy, and MRI. Ferumoxytol leaks out of blood vessels in areas of inflammation and is taken up by immune cells called macrophages, which congregate at sites of inflammation. (AMAG Pharmaceuticals, which markets ferumoxytol under the name Feraheme, was not involved in the study.)Autoimmunity and inflammation directed against the pancreas and its insulin-producing beta cells underlie the development of type 1 diabetes. However, while tests for autoantibodies (antibodies against the pancreas) can reveal whether a patient’s immune system has at some point attacked the pancreas, these antibodies are not always a good marker for predicting whether a given individual will develop full-blown diabetes.”Many people have genetic variants that put them at risk for type 1 diabetes,” explained study co-lead author Jason Gaglia, M.D., M.M.Sc., an assistant investigator in the Section of Immunobiololgy at Joslin. “Some develop autoimmunity, but only a small number develop clinical disease.”In addition, the development of therapies that could potentially halt patients’ progression from pancreatic inflammation to diabetes has been hampered by the long lead times needed in order to tell whether a given therapy has an effect.”If you want to study in people an immunodulatory agent right now, for diabetes it takes years,” Gaglia said. He explained that the end measurements for whether such therapies work relate directly to pancreatic function, changes in which may not become apparent for a long time. With imaging, he continued, “you could have an answer in a matter of months.”For the study, Gaglia and his collaborators — including study co-lead author Mukesh Harisinghani, M.D., of Massachusetts General Hospital — recruited 11 patients with newly diagnosed type 1 diabetes and evidence of antibodies against the pancreas. They also recruited 10 controls with no sign or family history of diabetes.To visualize inflammation across the whole pancreas, the researchers adapted MRI mapping algorithms originally developed for whole brain scanning. All other components of the experiment, including MRI equipment and ferumoxytol, are widely available.Gaglia notes that the ferumoxytol dose used in this imaging study is approximately one quarter of the dose used therapeutically for iron replacement. “These are all off-the-shelf components,” he said. “Other centers can do this now.”Ferumoxytol-MRI images of the patient group showed clear evidence of ferumoxytol accumulation in the pancreas, indicating ongoing inflammation. By comparison, images from the control group did not.The researchers believe this imaging technique could have a range of applications in diabetes research and help build a better understanding of the natural history of type 1 diabetes. Already, Gaglia said, the ferumoxytol-MRI images revealed that in their patient group, “inflammation was not uniform across the entire pancreas. There was also a large amount of variation between individuals, which aligns with what you see clinically. That’s never been shown in living humans before.”This imaging approach could also, in the future, help better define which patients with autoimmunity will likely progress to diabetes and classify subgroups of patients who might benefit from different therapeutic strategies. It could also identify those patients with early signs of autoimmunity who might be good candidates for clinical research studies.”Only about 5 percent of the first-degree family members of a person with diabetes will develop occult disease,” Gaglia, who is firm that for the moment this imaging technique should only be used in the context of research. “It might make sense to scan people in that group to see who is likely to progress and who isn’t. Those who are progressing may be the ones you would want to recruit for research on immunomodulatory therapies.”For more information: www.joslin.org FacebookTwitterLinkedInPrint分享 News | Neuro Imaging | July 05, 2019 Delta T1 Maps Provide Quantitative, Automated Solution to Assess Brain Tumor Burden Imaging Biometrics LLC (IB) a subsidiary of IQ-AI Ltd., is highlighting a recently published study in the American… read more News | Image Guided Radiation Therapy (IGRT) | July 16, 2019 AAPM 2019 Features More Than 40 Presentations on ViewRay’s MRIdian MRI-guided Radiotherapy ViewRay Inc. announced that the company’s MRIdian System is the focus of more than 40 abstracts selected by the… read more Two brain metastases from primary lung cancer are contrast enhanced in the brain of a 61-year-old male. Speakers at AHRA 2019 will state that ProHance and other macrocyclic MR agents present a very low risk to patients. Images courtesy of Bracco News | Magnetic Resonance Imaging (MRI) | August 01, 2019 | Jeff Zagoudis, Associate Editor FDA Issues Draft Guidance on Medical Device Safety in MRI Environment The U.S. Food and Drug Administration (FDA) issued a new draft guidance titled Testing and Labeling Medical Devices for… read more Technology | Contrast Media | July 15, 2019 FDA Approves Bayer’s Gadavist Contrast for Cardiac MRI in Adult Coronary Artery Disease Patients The U.S. Food and Drug Administration (FDA) has approved Gadavist injection for use in cardiac magnetic resonance… read more Images of regions of interest (colored lines) in the white matter skeleton representation. Data from left and right anterior thalamic radiation (ATR) were averaged. Image courtesy of C. Bouziane et al.